Venezuelan migration, one of the most significant migration crises in Latin America, has profoundly impacted migrants’ mental health, with Post-Traumatic Stress Disorder (PTSD) being a primary concern. This study aims to develop an integrative psychotherapeutic model based on expression, arts, creativity, and mindfulness (Mindfulness-Based Creative Art Expressive Therapy, MBCAET) for the treatment of PTSD in migrants. A qualitative methodology was employed using content analysis, incorporating bibliographic sources on mindfulness-based therapies, Gestalt therapy, and creative arts therapies (CATs). Additionally, records from mindfulness-based emotional support groups conducted by the Venezuelan Foundation for Psychology of Art (FUNVEPSIARTE) between 2018 and 2024 were analyzed. Findings revealed that MBCAET integrates psychotherapeutic and artistic approaches, fostering emotional regulation, creative expression, and identity reconstruction in migrants with PTSD. However, limitations were identified in the empirical validation and standardization of the model. In conclusion, MBCAET represents a promising approach to addressing PTSD in migrants by combining mindfulness techniques with creative arts. Further research is necessary to validate its effectiveness and adaptability across diverse cultural contexts.